What are the best peptides?
Reviewed by Kyle Hoedebeche
Written by Peter Arian
Published Nov 20, 2024

Peptides have become one of the most exciting buzzwords in modern wellness, longevity, and performance medicine. You’ll see them mentioned in fitness circles, skin health, weight management, and even cognitive support. But what exactly are peptides, and should you be on them?

This guide breaks it down in a way that’s easy to understand.

What Are Peptides?

Peptides are short chains of amino acids. They are usually made up of 2-50 amino acids. The same building blocks that make up proteins. You can think of them as “mini proteins” that act like messengers in the body. Because they’re smaller than full proteins, they’re easier for the body to absorb and can target specific receptors with high precision.

Your body naturally produces hundreds of peptides every day. They help regulate:

Modern peptide therapies work by supporting or amplifying the body’s natural signaling pathways in a more targeted and controlled way. Unlike traditional synthetic growth hormone (HGH), peptides stimulate your own physiologic hormone pulses rather than overriding them, which generally leads to fewer and more predictable side effects.

Why Are Peptides Used in Health and Wellness?

Because each peptide has a specific and predictable effect, they can be used to support a wide range of goals and are most effective when targeted. Some of the most common categories include:

1. Metabolism & Weight Management

Certain peptides help regulate blood sugar, appetite, fat burning, and metabolic rate. Examples include GLP-1 agonists, AOD-9604, and MOTS-c.

2. Muscle Growth

Peptides like CJC-1295/Ipamorelin or Tesamorelin stimulate natural growth hormone pulses, helping with muscle building, reduced fat, faster recovery, and deeper sleep.

3. Healing, Injury Support, and Recovery

BPC-157, TB-500, KPV, and GHK-Cu support tissue repair, reduce inflammation, and accelerate recovery from strains or injuries.

4. Cognitive & Mood Support

Peptides like Semax, Selank, and Dihexa can enhance focus, mood stability, and mental clarity.

5. Longevity & Cellular Health

Peptides such as Epitalon or NAD-related compounds work at the cellular level to improve energy production, repair DNA damage, and support healthy aging.

6. Skin & Aesthetic Benefits

GHK-Cu is widely used in skincare for collagen production, elasticity, pigmentation, and wound healing.

How Are Peptides Taken?

Delivery methods vary depending on how the peptide works:

Each method is chosen to maximize how well the peptide binds to its target receptor.

Are Peptides Safe?

When sourced through licensed pharmacies, peptides are generally considered safe and well-tolerated. Because many mimic natural processes in the body, side effects tend to be mild and reversible. The key is working with a provider who understands dosing, cycling, and quality, especially since the market is filled with unregulated “research chemical” websites.

Medical-grade peptides should always come with:

What are 503A Compounding Pharmacies?

These are patient-specific compounding pharmacies.

They make medications only after receiving an individual prescription for a named patient.

Key points:

These are the pharmacies used in concierge practices (like Bowery Clinic).

Who Uses Peptides?

Peptides are used by a wide spectrum of people:

Because peptides are modular and targeted, protocols can be customized for nearly any goal.

CategoryPeptides (BPC-157, TB-500, GHK-Cu)Traditional Medications (NSAIDs, Steroids, Muscle Relaxers, Pain Meds)
Primary PurposeAccelerate tissue repair, reduce inflammation, improve healing qualityReduce pain/inflammation or suppress symptoms short-term
How They WorkSignal the body to regenerate tissue, increase blood flow, and improve cellular repair pathwaysBlock inflammation pathways (NSAIDs), suppress immune response (steroids), mask pain (opioids/analgesics), relax muscles (cyclobenzaprine)
Effect on HealingSupports and speeds up actual healing of tendons, ligaments, muscle, and skinDoes not promote healing; mainly symptom control
Impact on Gut / Systemic StressGentle on stomach; minimal systemic stressNSAIDs can irritate stomach lining; steroids stress endocrine system; pain meds can cause dependency
Inflammation ControlReduces harmful inflammation while supporting healthy repairBroad suppression — may slow long-term tissue healing
Side EffectsTypically mild (fatigue, mild headaches, injection site irritation)Can include GI issues, water retention, hormonal disruption, drowsiness, dependency risk
Long-Term UseCan be used for extended periods under guidanceLong-term use discouraged for NSAIDs, steroids, opioids
Best ForInjuries, post-surgery recovery, tendon/ligament healing, chronic inflammation, performance recoveryAcute pain, inflammation spikes, short-term symptom relief
Onset of EffectsGradual but compounding (days–weeks)Fast symptom relief (minutes–hours), temporary
Why People Choose ThemHealing-focused, supports mobility, low side effect profile, complements PT/chiroImmediate symptom relief, widely available & familiar

The 5 major categories of peptides

We’re at the early stages of peptide medicines. New compounds are emerging every year, and their potential spans far beyond weight loss or muscle building. They offer a meaningful shift toward precision **care **treatments designed to work with the body, not against it.

As more research develops, peptides are positioned to become core tools in preventative care, metabolic health, aging, and cognitive support.

1. Repair & Recovery Peptides

PeptideMechanismKey BenefitsTypical Use
BPC-157 (Body Protection Compound)Increases angiogenesis and collagen formation; modulates nitric oxide and growth factor responseAccelerates healing of muscles, tendons, ligaments, and gut lining; reduces inflammationSoft tissue injuries, gut healing, recovery post-surgery
TB-500 (Thymosin Beta-4)Mobilizes actin and promotes cell migrationImproves wound and tendon healing, enhances endurance, reduces inflammationOften stacked with BPC-157 for synergistic recovery
KPV (α-MSH fragment)Anti-inflammatory peptide that modulates immune responseHelps with IBS, ulcerative colitis, inflammatory skin conditionsUsed in GI support stacks or topical anti-inflammatory formulations
GHK-Cu (Copper Peptide)Promotes tissue remodeling, collagen synthesis, and antioxidant activityImproves skin elasticity, hair regrowth, wound healingTopical, injectable, or microneedling serum

2. Cognitive & Stress Modulators

PeptideMechanismKey BenefitsTypical Use
SelankSynthetic analog of tuftsin (immune peptide); modulates serotonin/dopamineReduces anxiety, improves mood and focus without sedationNasal spray or injection; often in “calm/focus” blends
SemaxDerivative of ACTH fragment; boosts BDNF and dopamine signalingEnhances focus, memory, neuroprotectionCognitive performance, ADHD, recovery from stress or trauma
DSIP (Delta Sleep-Inducing Peptide)Regulates sleep cycles and cortisolImproves deep sleep, reduces nighttime awakenings, supports recoveryUsed at night in longevity or recovery stacks

3. Growth Hormone Secretagogues (GHS)

PeptideMechanismKey BenefitsTypical Use
IpamorelinMimics ghrelin to stimulate GH release without affecting cortisol or prolactinMuscle growth, fat loss, recovery, improved sleep200–500 mcg daily or before bed
CJC-1295 (w/ or w/o DAC)GHRH analog that increases GH and IGF-1 levelsIncreases lean muscle, fat metabolism, tissue repairOften stacked with Ipamorelin for synergistic GH pulse
SermorelinGHRH analog (shorter-acting than CJC)Increases natural GH output; improves sleep and recoveryNightly injections for GH support
TesamorelinSynthetic GHRH that strongly raises IGF-1 and reduces visceral fatTargets abdominal fat reduction, metabolic improvementCommon in longevity and weight loss stacks

4. Metabolic & Fat-Loss Peptides

PeptideMechanismKey BenefitsTypical Use
AOD-9604 (Fragment of hGH)Stimulates lipolysis and inhibits lipogenesisPromotes fat loss without affecting blood sugarDaily subcutaneous injection; often combined with MOTS-c or Ipamorelin
MOTS-cMitochondrial-derived peptide regulating metabolic homeostasisImproves insulin sensitivity, endurance, and cellular energyAnti-aging and metabolic stacks; 5–7 day cycles
GLP-1s (Semaglutide, Tirzepatide)Incretin mimetics regulating appetite and insulinWeight loss, blood sugar control, appetite suppressionCore Juna treatment offering

5. Longevity & Mitochondrial Peptides

PeptideMechanismKey BenefitsTypical Use
EpitalonTelomerase activator; regulates circadian rhythmCellular longevity, improved sleep, immune supportCycled 10–20 days; anti-aging programs
NAD+ (Coenzyme, not peptide but often included)Increases mitochondrial ATP production and DNA repairEnergy, cognitive clarity, anti-agingInjections or IVs 25–500 mg
NAD+ Precursors (NMN, NR)Raise NAD+ levels intracellularlyLongevity, metabolic healthOral daily supplement

Do You Need a Prescription for Peptides?

Yes. All compounded peptides require a prescription to be used safely and legally.

Bowery Clinic is a concierge longevity and peptide virtual clinic designed for people who want a higher standard of care than traditional telemedicine. We focus on advanced peptide therapy, recovery, muscle optimization, metabolic support, and long-term vitality.

At Bowery Clinic, all treatments are dispensed through licensed 503A, FDA-registered compounding pharmacies, ensuring high-quality peptides with verified sterility, potency, and COAs. No unregulated sources. No “research peptides.” No risks from black-market products.

You can learn more by clicking the link here.

Advancing peptide research through quality, innovation, and scientific excellence.
The statements made within this website have not been evaluated by the US Food and Drug Administration. The products we offer are not intended to diagnose, treat, cure or prevent any disease.
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