Semax + Selank should be used with clinician oversight, particularly in patients taking psychiatric, neurologic, stimulant, sedative, or sleep medications. The published research base is smaller and geographically more limited than the evidence for standard U.S. psychiatric medications, and long-term safety data are not extensive. Intranasal use can cause nasal irritation, dryness, headache, or an unpleasant taste, and some patients may notice changes in sleep, stimulation, or mood. Your clinician will review your full medication list and mental-health history before treatment.